منابع مشابه
Additive Manufacturing – IDH Perspective
Additive Manufacturing (AM) technologies build near-net shape components one layer at a time using data from 3D CAD models. AM technologies are the result of evolution of work in 3D printing and stereolithography (the STL files used to convert 3D CAD to layers for building parts come from stereolithography terminology) and could revolutionize many sectors of U.S. manufacturing by reducing compo...
متن کاملDetection, Characterization, and Inhibition of FGFR-TACC Fusions in IDH Wild-type Glioma.
PURPOSE Oncogenic fusions consisting of fibroblast growth factor receptor (FGFR) and TACC are present in a subgroup of glioblastoma (GBM) and other human cancers and have been proposed as new therapeutic targets. We analyzed frequency and molecular features of FGFR-TACC fusions and explored the therapeutic efficacy of inhibiting FGFR kinase in GBM and grade II and III glioma. EXPERIMENTAL DES...
متن کاملInherited variant on chromosome 11q23 increases susceptibility to IDH-mutated but not IDH-normal gliomas regardless of grade or histology.
INTRODUCTION Recent discoveries of inherited glioma risk loci and acquired IDH mutations are providing new insights into glioma etiology. IDH mutations are common in lower grade gliomas and secondary glioblastomas and uncommon in primary glioblastomas. Because the inherited variant in 11q23 has been associated with risk of lower grade glioma and not with glioblastomas, we hypothesized that this...
متن کاملStructural and Functional analysis of Staphylococcus aureus NADP-dependent IDH and its comparison with Bacterial and Human NADPdependent IDH
Staphylococcus aureus a natural inhabitant of nasopharyngeal tract mainly survives as biofilms and possess complete Krebs cycle which plays major role in its pathogenesis. This TCA cycle is regulated by Isocitrate dehydrogenase (IDH) we have earlier cloned, sequenced (HM067707), expressed and characterized this enzyme from S. aureus ATCC12600. We have observed only one type of IDH in all the st...
متن کاملIDH Mutations: Genotype-Phenotype Correlation and Prognostic Impact
IDH1/2 mutation is the most frequent genomic alteration found in gliomas, affecting 40% of these tumors and is one of the earliest alterations occurring in gliomagenesis. We investigated a series of 1305 gliomas and showed that IDH mutation is almost constant in 1p19q codeleted tumors. We found that the distribution of IDH1(R132H) , IDH1(nonR132H) , and IDH2 mutations differed between astrocyti...
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ژورنال
عنوان ژورنال: Clinical Lymphoma Myeloma and Leukemia
سال: 2020
ISSN: 2152-2650
DOI: 10.1016/s2152-2650(20)30440-7